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非甾体抗炎药和对乙酰氨基酚能增加患银屑病和银屑病关节炎的风险

上一篇 / 下一篇  2014-06-05 13:59:29 / 个人分类:银屑病关节炎专题

  

译者:王泉丽       校对:李玉翠       审核:张改连

  AbstractNon-steroidal anti-inflammatory drugs (NSAIDs) have been reported to induce or exacerbate psoriasis. We aimed to evaluate the association between several widely used analgesics, including aspirin, nonaspirin NSAIDs, and acetaminophen (paracetamol), and risk of psoriasis and psoriatic arthritis(PsA) in a large cohort of US women, the Nurses' Health Study II (1991-2005). Information on regular use of aspirin, NSAIDs, and acetaminophen was collected for 95,540 participants during the follow-up. During 1,321,280 person-years of follow-up, we documented 646 incident psoriasis cases and 165 concomitant PsA cases. Compared to women who reported no use, regular acetaminophen and NSAIDs users with more than 10 years of use had multivariate hazard ratios of 3.60 [95% confidence interval (CI): 2.02-6.41] of psoriasis and 2.10 (95% CI: 1.11-3.96) for PsA. There was no clear association between aspirin and risk of psoriasis or PsA. In conclusion, long-term acetaminophen and NSAIDs use may be associated with an increased risk of PsA. Special attention on psoriasis and PsA screening may be needed for those who are prescribed for acetaminophen and NSAIDs.

        有报道称非甾体抗炎药能诱发或加重银屑病。我们在1991年至2005年期间对美国女性进行大型队列研究,目的是评估使用阿司匹林及其他非甾体抗炎药、对乙酰氨基酚(扑热息痛)等止痛药患银屑病和银屑病关节炎的风险。在这期间随访收集了规律使用阿司匹林,非甾体抗炎药及对乙酰氨基酚的美国女性共95,540 人。期间共有1,321,280人次进行了随访,共有646例出现银屑病,165例伴有银屑病关节炎。使用乙酰氨基酚和非甾体抗炎药超过10年的与未使用上述药物的人群相比患银屑病的风险增加了 3.6095%可信区间:2.02-6.41 银屑病关节炎的风险增加了 2.1095%可信区间:1.11-3.96 阿司匹林与银屑病和银屑病关节炎的关系尚未明确,总之,长期使用对乙酰氨基酚和非甾体抗炎药能增加患银屑病关节炎的风险。使用过乙酰氨基酚和非甾体抗炎药的人群要特别注意进行银屑病及银屑病关节炎筛查。

       引自:Wu S, Han J, Qureshi AA.Use of Aspirin, Nonsteroidal Anti-inflammatory Drugs, and Aceta-minophen (Paracetamol), and Risk of Psoriasis and Psoriatic Arthritis: A Cohort Study.Acta Derm Venereol. 2014 Apr


TAG: 关节炎 银屑病

引用 删除 11   /   2015-04-20 21:25:21
张老师你好,我是一个实习医生,在网上看到你曾经发表过的文章关于非甾体类抗炎药加重银屑病关节炎的,我想问问你下为什么非甾体类消炎药会不适用于银屑病关节炎
我来说两句

 
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